Search results for "New World"
showing 10 items of 12 documents
CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells
2018
CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Here, we fused these VHH domains to the hinge, CH2, and CH3 domains of human IgG1, yielding highly soluble chimeric llama/human heavy chain antibodies (hcAbs). We analyzed the capacity of these hcAbs to mediate complement-dependent cytotoxicity (CDC) to CD38-expressing human multiple myeloma and Burkitt lymp…
A revision of the new world species of Polytrichophora Cresson and Facitrichophora, new genus (Diptera, Ephydridae)
2012
The New World species of Polytrichophora Cresson and Fascitrichophora new genus, are revised. Fifteen new species are described (type locality in parenthesis): Fascitrishophora atrella sp. n. (Costa Rica. Guanacaste: Murciélago [10°56.9’N, 85°42.5’W; sandy mud flats around mangrove inlet]), F. carvalhorum sp.n. (Brazil. São Paulo: Praia Puruba [23°21’S, 44°55.6’W; beach]), F. manza sp. n. (Trinidad and Tobago. Trinidad. St. Andrew: Lower Manzanilla (12 km S; 10°24.5’N, 61°01.5’W), bridge over Nariva River), F. panama sp. n. (Panama. Darien: Garachine [8°04’N, 78°22’W]), Polytrichophora adarca sp. n…
Krāsas 20. gadsimta antiutopiskajos romānos
2017
Šīs pētījums apskata krāsu izmantošanu, valodu un simbolismu 20. gadsimta antiutopiskajā literatūrā. Darba pamatuzdevums ir izpētīt krāsu paleti antiutopiskajos romānos: kādi krāsu termini ir izmantoti, kādas ir to galvenās funkcijas, simbolisms un konteksts. Lai sasniegtu šo mērķi, ir apskatīti pētījumi par krāsu simbolismu, kā arī tika savākti dati priekš kvantitatīvas and kvalitatīvas analīzes. Tika secināts, ka romānos Mēs, Brīnšķīgā jaunā pasaule un Kalpones stāsts izmantotās krāsas pārsvarā ir bāziskie krāsu termini, saskaņā ar Berlina un Keja teoriju. Terminiem ir trīs galvenās funkcijas: individualizēt varoni, akcentēt ‘utopisko’ valsts pilsoņu vienādību un raksturot ‘utopisko’ vals…
CAUSES AND CONSEQUENCES OF THE 2008-2009 INTERNATIONAL FINANCIAL CRISIS
2012
The paper investigates the current crisis and its major consequences in a shifting world. Originated from the USA, the crisis spread in the world and disturbed its power distribution. The emerging countries development of the last two decades illustrates the catching-up process. The findings also confirm the increased role of the Chinese economy today. The Chinese growth in comparison with the USA economic path is a mirror for the future world architecture. The consequences of the international financial crisis are focused on the fact that the developed countries will lose gradually their privileges in the shifting of economic power.
Mapping CAP-A satellite DNAs by FISH in Sapajus cay paraguay and S. macrocephalus (Platyrrhini, Primates)
2023
Satellite DNAs such as Cap-A sequences are potentially informative taxonomic and phylogenetic markers useful for characterizing primate genomes. They have also been used as cytogenetic markers facilitating species identification in many taxa. The aim of this work is to map Cap-A sequences by FISH (fluorescent in situ hybridization) on two Platyrrhini (Primates) species genomes, Sapajus cay paraguay and S. macrocephalus, in order to study their distribution pattern on chromosomes. The Cap-A probes showed bright signals with almost the same interstitial pattern of distribution in correspondence with C and CMA3 rich regions on six pairs of chromosomes in both Sapajus species. An additional pai…
Ejaculate fractioning effect on llama sperm head morphometry as assessed by the ISAS(®) CASA system.
2013
Contents South American camelid sperm characteristics are poorly known compared with those of other domestic animals. The long-term duration of ejaculation makes difficult to gather all the seminal fluid, implying possible ejaculation portion losses. Thus, the aim of this research was to evaluate the characteristics of the morphology and morphometry of the spermatozoa change during ejaculation. The morphometric characterization was tested on nine specimens of the Lanuda breed, using a special artificial vagina. In five of the animals, a fractioning of the ejaculate was performed by taking samples every 5 min. for a total of 20 min. Air-dried seminal smears were stained with Hemacolor and mo…
«Was not the labour problem the same everywhere». «Homo ad laborem nascitur et avis ad volatum»! (Prolegomena per uno studio del diritto del lavoro t…
2019
The purpose of this research is to catalogue the biblical texts - notably in a first phase those which are in the first (or old) testament of the Christian Bible - which contain both prescriptive structures and pathways designed to protect the position of social weakness of the "worker", understood in its broadest sense and in its various and diverse facets: worker, salaried employee, servant, even slave, and so on. The starting point and most immediate objective of this work is therefore to find the biblical sources - and to get ready one first critical apparatus - which refer, directly or indirectly, to work in a broad sense, that is a personal relationship in which one of the two subject…
A revision of the new world species of Gymnoclasiopa Hendel (Diptera, Ephydridae)
2012
Species of the shore-fly genus Gymnoclasiopa Hendel from the New World are revised, including G. grecorum, sp. n. (Alaska. Juneau: Gastineau Channel, Thane Road (S Juneau; 58°16.9’N, 134°22.4’W)) and G. matanuska, sp. n. (Alaska. Matanuska-Susitna: Palmer (Matanuska River; 61°36.5’N, 149°04.1’W)). We also clarify the status of previously described species, including those now discovered to have Holarctic distributions and/or for which sexual dimorphism was not appreciated and the species was described twice, including G. montana (Cresson) as a syn. n. of G. bohemanni (Becker). Two species, G. bella (Mathis), comb. n., and G. chiapas (Mathis), comb. n., are transferred from Ditrichophora to …
A revision of the shore-fly genus Hydrochasma Hendel (Diptera, Ephydridae)
2013
A revision of the shore-fly genus Hydrochasma Hendel. The species of the genus Hydrochasma Hendel are revised, including 27 new species (type locality in parenthesis): H. andeum (Ecuador. Guayas: Boliche (02°07.7'S, 79°35.5'W)), H. annae (United States. Utah. Grand: Swasey Beach (15.3 km N Green River; 39°07'N, 110°06.6'W; Green River; 1255 m)), H. capsum (Ecuador. Orellana: RíoTiputini (0°38.2'S, 76°8.9'W)), H. castilloi (Ecuador. Loja: Catamayo (03°59'S, 79°21'W)), H. crenulum (Peru. Cuzco: Paucartambo, Atalaya (Río Alto Madre de Dios; 12°53.3'S, 71°21.6'W; 600 m)), H. denticum (Ecuador…
New discoveries in New World Atissini as revealed in revision of Pelignellus Sturtevant & Wheeler (Diptera: Ephydridae)
2019
Pelignellus is resurrected from synonymy with Atissa and is revised. The genus and both included species—P. subnudus Sturtevant & Wheeler from the USA (California) and P. freidbergi n. sp. from Central America (Costa Rica, El Salvador, Panama)—are described with an emphasis on structures of the male terminalia, which are fully illustrated. The species are keyed and their distribution data are provided. For perspective and to facilitate recognition of genera and species, the tribe Atissini is diagnosed and a key to genera is provided.